Alzheimer's Disease
Conditions
Interventions
Experimental group:rTMS real stimulation combined with bright light therapy
control group:rTMS real stimulation combined with natural light
control group:Sham rTMS combined with bright light therapy
control group:Sham rTMS stimulation combined with natural light
Sponsors
Beijing Geriatric Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Right-handed; Age >=60 years old, both sexes; 2. Can cooperate with rTMS and bright light treatment; 3. Mild and moderate AD: Montreal Cognitive Assessment (MoCA, Beijing version) score > 15, CDR < 2 (mild and moderate dementia); The disease duration was less than 10 years; No long-term use of sedative-hypnotic drugs, or stable use of AD treatment drugs for more than 4 weeks, and no drug dose adjustment during the treatment period; 4. The degree of education is the third grade of primary school or above; 5. Subjects and their guardians or legal representatives agreed to participate in the study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Complicated with other neurological and mental diseases, severe heart, liver, lung, kidney diseases and other serious system diseases; 2. With metal implants such as cardiac pacemakers, coronary stents and aneurysm clips, or with ferromagnetic materials such as cochlear implants; 3. Severe aphasia, agnosia, apraxia and deafness; 4. Patients with serious eye diseases and skin diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in PSQI scale scores before and after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wearable devices monitor sleep data;Melatonin and reactive oxygen species levels in the blood;Excitatory and inhibitory neurotransmitters; | — |
Countries
China
Contacts
Public ContactYueqing Hu
Beijing Geriatric Hospital
Outcome results
None listed