Ischemic stroke
Conditions
Interventions
Group D:Inject 0.5ug/kg dexmedetomidine before anesthesia induction for 10 minutes
Low dose infusion of dexmedetomidine 0.1ug/kg/h with in 72 hours after surgery.
Group ND:Blank control(Normai Saline of equal volume)
Sponsors
Civil Aviation General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old with occlusion of intracranial segment, internal carotid artery or middle cerebral artery M1 and M2 segments; 2. Within 6 hours of onset, the mRS score before the onset of the disease was <=2 points, and the mechanical thrombectomy was treated
Exclusion criteria
Exclusion criteria: 1. Intracranial hemorrhage, cerebral infarction area exceeding 1/3 of the anterior circulation blood supply area, dissection; 2. History of contrast agent allergy; Has active bleeding or a history of known bleeding tendency; 3. mRS > 3 points before onset; ASPECT score < 7; responsible for vascular non-anterior circulation; 4. Severe heart, lung and kidney dysfunction: breastfeeding or other inappropriate to receive EVT.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cerebral hyperperfusion syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale score;30 day mortality rate;Total length of hospital stay;Intensive care unit ; National Institute of Health stroke scale score;Time of occurrence of cerebral hyperperfusion syndrome;Duration of cerebral hyperperfusion syndrome;Rate of vasoactive drugs;High systolic blood pressure;Minimum systolic blood pressure;The difference between the maximum and minimum systolic blood pressure values;The time when the mean arterial pressure is less than 70mmHg;Maximum heart rate;Minimum heart rate;Postoperative extended Thrombolysis score;Serum interleukin-6;Serum s100-ß protein;Serum tumor necrosis factor-a;Height;Weight;Age;Gender;Obstruction site;Underlying disease;Fluid balance;Blood pressure;Heart rate;Propofol dosage;Time from entering the operating room to recanalization of blood vessels;Surgical duration;Anesthesia duration;Pulse oxygen saturation;Ispectral Index;The incidence of postoperative pneumonia;Thrombolytic therapy or not;Dose of sufentanil;Dose of remifentanil;Etomidate dosage;Atropine addition rate/ dosage;Norepinephrine addition rate/dose;Nicardipine addition rate/dose;Number of cases where medication infusion was stopped midway; | — |
Countries
China
Contacts
Public ContactShu Li
Civil Aviation General Hospital
Outcome results
None listed