Immune checkpoint inhibitors-induced liver injury
Conditions
Interventions
Sponsors
Ruijin Hospital, Shanghai Jiaotong University, School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) malignant tumor patients with grade 3 or above liver injury after receiving immune checkpoint inhibitors (2) There was no significant improvement in liver function after 3 days of glucocorticoid treatment; (3) ECOG PS score <= 2; (4) age between 18 and 75 years old, male or female; (5) Willing to sign The informed consent form.
Exclusion criteria
Exclusion criteria: (1) severe infection and active tuberculosis; (2) uncontrolled diabetes and hypertension; (3) multiple organ failure; (4) end-stage malignant tumors; (5) pregnant and lactating women;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Secondary Infection;hyperglycaemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| liver function test;coagulation function; | — |
Countries
China
Contacts
Public ContactLi Chen
Ruijin Hospital, Shanghai Jiaotong University, School of Medicine
Outcome results
None listed