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Impact of Omega-3 Fatty Acids Regulating PINK1/Parkin-mediated Mitophagy on Visual Function in AMD Patients

Impact of Omega-3 Fatty Acids Regulating PINK1/Parkin-mediated Mitophagy on Visual Function in AMD Patients

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105085
Enrollment
Unknown
Registered
2025-06-27
Start date
2025-06-30
Completion date
Unknown
Last updated
2025-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age related macular degeneration

Interventions

Control group (standard treatment alone):standard treatment
Intervention group (standard treatment + Omega-3 fatty acid supplementation):standard treatment+Omega-3 fatty acid supplements

Sponsors

Shenzhen Eye Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Diagnosed with AMD;

Exclusion criteria

Exclusion criteria: 1.Uncontrolled glaucoma in the study eye (defined as intraocular pressure >= 30 mmHg despite standard treatment or based on investigator's judgment during screening/baseline). 2.Active intraocular or periocular inflammation/infection (e.g., keratitis). 3.Severe opacity of refractive media in the study eye precluding acquisition of adequate-quality ocular imaging (e.g., SD-OCT, FA, CFP), which may compromise safety/efficacy assessments. 4.Hereditary hemorrhagic tendency or coagulation disorders. 5.Use of Omega-3 dietary supplements within 3 months prior to enrollment. 6.History of vitreous surgery.

Design outcomes

Primary

MeasureTime frame
BCVA?OCT?OCTA,Microperimetry,mfERG, Levels of mitophagy-related proteins, Inflammatory markers, Cytokines, Gene expression;

Countries

China

Contacts

Public ContactZhang Shaochong

Shenzhen Eye Hospital

zhangshaochong@gzzoc.com+86 755 2395 9625

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026