1. Acute Respiratory Distress Syndrome(ARDS)
Conditions
Interventions
Respiratory-Dynamics Monitoring Feedback (RDMF) Group:REal-time Algorithm-driven Ventilation feedback to improve lung-protective ventilation in critically
Conventional Monitoring (CM) Group:Clinicians only adjust the ventilator parameters according to the traditional way of adjusting breathing.
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 75 years; 2.Receiving invasive mechanical ventilation via endotracheal intubation at the time of screening; 3.Initiated mechanical ventilation within the past 24 hours; 4.PaO2/FiO2 =8 cmH2O (or, if arterial blood gas unavailable, SpO2/FiO2 =72 hours after enrolment.
Exclusion criteria
Exclusion criteria: 1.Receiving extracorporeal membrane oxygenation (ECMO) or high-frequency oscillatory ventilation; 2.Chronic ventilator dependence (>= 21 consecutive days of ventilation prior to admission); 3.Brain death or life-sustaining treatment withdrawal anticipated within 72 hours; 4.Pregnancy; 5.Known neuromuscular disease affecting spontaneous respiratory effort; 6.Prisoners or individuals unable to provide surrogate consent; 7.Simultaneous enrolment in another interventional ICU study; 8.Lack of digital infrastructure for real-time ventilator waveform acquisition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung Protection Ventilation Bundles Achievement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ventilator-free days at day 28 (VFD-28);ICU length of stay;ECMO initiation rate;Clinician satisfaction and perceived workload;Incidence of barotrauma;Incidence of ventilator-associated pneumonia (VAP);Intervention Adherence Indicator;Inflammatory biomarkers;Mortality at day 28; | — |
Countries
China
Contacts
Public ContactLongxiang Su
Peking Union Medical College Hospital
Outcome results
None listed