Acute myeloid leukemia
Conditions
Interventions
Therapy group:Undergo induction therapy with the VCMG regimen
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) The patient or legal guardian voluntarily participates and signs the informed consent form; (2) The patient's life expectancy is at least 12 weeks; (3) Patients are not suitable for intensive chemotherapy, defined as follows: Age >= 75 years, or age 18-74 years, and meeting all of the following criteria: a) Eastern Cooperative Oncology Group (ECOG) score of 2 or 3 b) History of chronic congestive heart failure, chronic stable angina, or left ventricular ejection fraction (LVEF) =50% c) Creatinine clearance rate >=30ml/min and 1.5 and = 75 years with ECOG score of 0-2, or age 18-74 years with ECOG score of 0-3; (5) Creatinine clearance rate >= 30 ml/min; (6) Alanine aminotransferase (ALT) <= 3.0 times the upper limit of normal (ULN), aspartate aminotransferase (AST) <= 3.0 times the upper limit of normal (ULN), total bilirubin <= 3.0 times the upper limit of normal (ULN) (excluding liver infiltration in leukemia).
Exclusion criteria
Exclusion criteria: (1) Patients with acute promyelocytic leukemia; (2) AML transformed from myeloproliferative neoplasms; (3) Patients with central nervous system leukemia; (4) Women who are pregnant or breastfeeding; (6) HIV-infected patients; (7) Patients with uncontrollable active infections; (8) Patients with active hepatitis B or C; (9) Suffering from mental illness; (10) The patient has drug abuse/addiction; (11) According to the researcher's judgment, the patient has other conditions that make them unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety;Progression-free survival rate;Overall survival rate; | — |
Countries
China
Contacts
Public ContactZhichao Li
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed