coronary heart disease
Conditions
Interventions
experimental group:The patients receive?evolocumab?(140 mg before PCI,once every 2 weeks)
control group:no intervention
Sponsors
The second hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.age between 18-80; 2.sign the Informed consent; 3.Diagnosis of ACS is planned for elective PCI, including unstable angina pectoris (UA), acute non-ST-elevation myocardial infarction (NSTEMI), acute ST-elevation myocardial infarction (STEMI); 4.Patients who took moderate-intensity statins (atorvastatin calcium tablets 20mg-40mg 1/night, or other statins of equivalent strength) for at least 4 weeks before enrollment still had an LDL >= 1.8mmol/L.
Exclusion criteria
Exclusion criteria: 1.Patients with acute myocardial infarction requiring emergency PCI; 2. Patients whose angiography results indicate PCI is either unnecessary or unfeasible; 3.The clinical condition is unstable,such as hemodynamic disorder or malignant arrhythmia, and the life expectancy is less than 3 months; 4.Heart function grade III-IV or EF<30%; 5. Severe renal dysfunction (eGFR<30ml/min); 6. Severe liver function injury, liver enzymes (ALT, AST) increased by more than 3 times; 7.Can not tolerate any dose of statin therapy, such as severe myolysis, liver function damage; 8. Patients with PCSK-9 inhibitor before inclusion; 9. Allergies to PCSK-9 inhibitors, statins and contrast agents; 10. Malignant tumor; 11. Severe ischemic or hemorrhagic brain stroke within 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of periprocedural myocardial injury and myocardial infarction ; | — |
Secondary
| Measure | Time frame |
|---|---|
| change of blood lipids before and one month after surgery;moniter Adverse Drug Reactions, including CK,AST,ALT,CCr before surgery and at 1 month postoperatively.;rate of MACE; | — |
Countries
China
Contacts
Public ContactXie Yanan
The second hospital of Hebei Medical University
Outcome results
None listed