Adolescents with Major Depressive Disorder
Conditions
Interventions
Adolescents with MDD group:None
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: Adolescents with Major Depressive Disorder (MDD) 1. Adolescents aged 10-18 years old; 2. Meeting the diagnostic criteria for Major Depressive Disorder as per DSM-5; 3. Obtaining written informed consent from the patient and their legal guardian. Healthy Controls 1. Children and adolescents aged 10-18 years old; 2. Obtaining written informed consent from the participant and their legal guardian.
Exclusion criteria
Exclusion criteria: Adolescents with Major Depressive Disorder (MDD) 1. Diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, autism spectrum disorder, or intellectual disability based on the Chinese version of the Mini-International Neuropsychiatric Interview (MINI) assessment; 2. Presence of intellectual disability with an IQ < 80; 3. Severe visual, auditory, or language impairments; 4. History of brain injury, epilepsy, or severe physical illnesses. Healthy Controls 1. Presence of any mental disorder; 2. Subthreshold depression, subthreshold mania, or high-risk mental illness syndrome; 3. Family history of mental disorders; 4. IQ < 80 as per the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV); 5. Severe visual, auditory, or language impairments; 6. History of brain injury, epilepsy, or severe physical illnesses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg Depression Rating Scale Score(MADRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function;Columbia Suicide Severity Rating Scale Score, C-SSRS;Hamilton Anxiety Scale Score;Electroencephalogram Data;MRI Data;Childhood Trauma Questionnaire Score;Hamilton Depression Rating Scale Score-32 Items;Young Mania Rating Scale Score;Sleep rhythm;The Pittsburgh Sleep Quality Index;Ostracism Experience Scale Score for Adolescents;Children and Adolescents Peer Relationship Scale Score; | — |
Countries
China
Contacts
Public ContactYanling Zhou
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed