Mycoplasma pneumoniae pneumonia
Conditions
Interventions
Experimental group:Doxycycline combined with methylprednisolone
Control group:Doxycycline
Sponsors
Children's Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
5 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Pneumonia patients who meet the hospitalization criteria (fever >= 5 days, oxygen saturation = 38.0 ?); (2) Coughing; 4.Course of disease < 10 days; 5.Meet the laboratory standards for mycoplasma infection, which means meeting any of the following criteria: (1) positive mycoplasma nucleic acid test: including MP-DNA or MP-RNA testing; (2)mycoplasma antigen test positive; 6.Meet the imaging findings: Chest X-ray or CT showing pulmonary consolidation of one or more lung lobes and no pulmonary complications such as pulmonary necrosis, pulmonary embolism, pleural effusion, etc; 7.The guardian of the subject who has signed the informed consent form fully understands the purpose of the trial, has a basic understanding of the pharmacological characteristics and possible adverse reactions of the trial drug, and voluntarily allows the child to participate in this trial and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Doxycycline or methylprednisolone has been used; 2.Contraindications for the use of methylprednisolone or doxycycline; 3.Course of fever>=10 days; 4.Existing pulmonary complications (pulmonary embolism, pulmonary necrosis, pleural effusion, plastic bronchitis, etc.); 5.Respiratory failure requiring mechanical ventilation; 6.Congenital bronchopulmonary dysplasia; 7.Serious basic diseases: including liver failure, kidney disease, heart failure, connective tissue disease, immunodeficiency disease, tumor, hypertension, diabetes, hemophagocytic syndrome, etc; 8.Children receiving other experimental drugs or instruments;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The fever reduction rate of children (with the fever subsiding and remaining normal for over 48 hours) within 5 days after enrollment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission rate and remission time of cough;Recovery status of chest imaging (chest X-ray or CT scan);White blood cell count;C-reactive protein;Lactic dehydrogenase;Liver function;D-Dimer;Ferritin;Pulmonary necrosis;Pulmonary embolism;Pleural effusion; | — |
Countries
China
Contacts
Public ContactChen Zhengrong
Children's Hospital of Soochow University
Outcome results
None listed