Tuberculosis
Conditions
Interventions
Control Group:Standard Treatment
Sponsors
Huzhou Center Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-75 years; 2.Radiographic findings consistent with pulmonary tuberculosis; 3.Sputum smear-positive for acid-fast bacilli (AFB) with GeneXpert confirmation of rifampicin-sensitive Mycobacterium tuberculosis; 4.Planned standard anti-TB treatment with 2HRZE/4HR regimen; 5.Willing to comply with study procedures and follow-up.
Exclusion criteria
Exclusion criteria: 1.Previous history of anti-tuberculosis treatment; 2.Pulmonary TB with concurrent extrapulmonary TB involvement; 3.Known hypersensitivity to atorvastatin or its excipients; 4.History of myopathy or hereditary muscle disorders; 5.Hepatic failure or decompensated cirrhosis; 6.Hypothyroidism (uncontrolled); 7.HIV infection; 8.Pregnant or lactating women; 9.Current use of immunosuppressive medications; 10.Use of any statin within 3 months prior to screening; 11.Conditions requiring long-term statin therapy based on cardiovascular risk: Familial hypercholesterolemia History of myocardial infarction or stroke; 12.Laboratory abnormalities at screening: ALT >5× upper limit of normal (ULN) eGFR 5× ULN Serum potassium <2.5 mmol/L; 13.Any other severe comorbidities deemed by investigators to compromise patient safety or study validity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| culture conversion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse Event;radiographic assessment; | — |
Countries
China
Contacts
Public ContactQingqiu Zeng
Huzhou Center Hospital
Outcome results
None listed