Postoperative cognitive dysfunction
Conditions
Interventions
Remimazolam group:In the remimazolam group, remimazolam was used for anesthesia induction and maintenance of intraoperative depth of anesthesia.
Propofol group:In the propofol group, propofol was used for anesthesia induction and maintenance of intraoperative anesthesia depth.
Sponsors
Heji Hospital Affiliated to Changzhi Medical College
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Age >= 60 years old, male or female; American Society of Anesthesiologists classification I-III; patients and their families agree to participate in the study.
Exclusion criteria
Exclusion criteria: Refusal to participate in the study or individuals who planned to undergo bronchoscopy therapy,a history of severe cardiac, cerebral, pulmonary,hepatic, renal, or metabolic diseases, a history of previous recovery from abnormal surgical anesthesia, ECG recording indicating HR < 50 beats/ min, a history of acute respiratory inflammation that had not been cured within 2 weeks, patients with neuromuscular or psychiatric disorders, individuals with esophageal reflux disease, those suspected of narcotic analgesics or sedatives abuse; predicted to have possible or had previous difficult airways, known to be allergic to fat emulsions, benzodiazepines and opioids, had participated in other drug trials within three months, or were unable to communicate effectively or were uncooperative.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE grade;MOAA/S grade;Serum GDNF factor level; | — |
Countries
China
Contacts
Public ContactGuoYan
Heji Hospital Affiliated to Changzhi Medical College
Outcome results
None listed