Obesity
Conditions
Interventions
Placebo group:Oral engineering Clostridium butyricum preparation (the same composition as the bacterium, no GLP-1)
Live bacteria intervention group:Oral engineered Clostridium butyricum GLP-1 agent (1×10^9 CFU/day)
Sponsors
Reproductive Hospital Affiliated to Jiangxi University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age and BMI: 18-65 years old, BMI >=30 kg/m^2 (obesity) or BMI>=27 kg/m62 with at least one obesity-related complication (such as hypertension, type 2 diabetes, non-alcoholic fatty liver disease). 2. Metabolic stability: fasting blood glucose =3.0.
Exclusion criteria
Exclusion criteria: 1. Comorbid diseases: severe liver and kidney insufficiency (ALT/AST> 3 times the upper limit, eGFR<30 mL/min/1.73m^2), inflammatory bowel disease, immunodeficiency or active tumor. 2. Drug interference: long-term use of glucocorticoids, immunosuppressants, or drugs that affect gastrointestinal motility (such as orlistat). 3. Pregnancy and breastfeeding: Women of childbearing age need to take effective contraceptive measures and have a negative pregnancy test. 4. History of allergies: allergy to E. coli or engineered bacterial carrier components
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stool high-throughput sequencing;Fecal GLP-1 content; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical indicators;Metabolic Parameters; | — |
Countries
China
Contacts
Public ContactChen Weijun
Reproductive Hospital Affiliated to Jiangxi University of Traditional Chinese Medicine
Outcome results
None listed