Breast cancer
Conditions
Interventions
Case series:None
Sponsors
Hubei Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosed as breast cancer patients through clinical pathological diagnosis (Age = 18 years old with ECOG score of 0-1); 2. Accompanied by localized edema of the breast skin (determined by clinical examination or imaging assessment); 3. Subjects included are newly diagnosed breast cancer patients who have not received any treatment for breast cancer prior to enrollment; 4. Patients judged by the investigator to have surgical opportunities, or expected to gain surgical opportunities after neoadjuvant therapy; 5. Approved by the ethics committee of our hospital.
Exclusion criteria
Exclusion criteria: 1. Mentally ill individuals; 2. Individuals with physical conditions unsuitable for surgery; 3. Those with other primary tumors or distant metastases; 4. Individuals with extensive inflammatory breast or skin involvement; 5. Those for whom clinical examination and breast ultrasound cannot determine skin edema; 6. Individuals with incomplete preoperative imaging data or postoperative pathological data; 7. Pregnant or breastfeeding women; 8. Those who have not signed the informed consent for treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether there is cancer cell infiltration in the dermis and subcutaneous fat layer at each detection point; | — |
Secondary
| Measure | Time frame |
|---|---|
| The expression of CD68 in the dermis and subcutaneous fat layer of each detection point;The expression of CD20 in the dermis and subcutaneous fat layer of each detection point;The expression of CD20 in the dermis and subcutaneous fat layer of each detection point; | — |
Countries
China
Contacts
Public ContactWu Xinhong
Hubei Cancer Hospital
Outcome results
None listed