Postoperative Delirium
Conditions
Interventions
P Group:The lung-protective ventilation strategy combined with permissive carbonia was used, the PCV-VG ventilation mode was selected, the tidal volume was set at 6–8 ml/kg (ideal body weight), the PE
C Group:The conventional ventilation strategy was adopted, the PCV-CG ventilation mode was selected, the tidal volume was set at 8–10 mL/kg (ideal body weight), the PEEP was set at 5 cmH2O, the inspir
Sponsors
Jiangsu Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elective laparoscopic radical colorectal cancer resection; 2. Age>=65 years; 3.BMI 18.5–28 kg/m^2; 4. ASA LEVELS II.–III.
Exclusion criteria
Exclusion criteria: 1. Diagnosed psychiatric illness before surgery, or MMSE score <17 before surgery; 2. History of cerebrovascular disease (such as cerebral embolism, cerebral hemorrhage or cerebral infarction, etc.); 3. Have a history of severe lung disease (such as severe COPD, lung infection, bronchiectasis or asthma, etc.); 4. There are contraindications to the use of PEEP (such as pulmonary bullae, intracranial hypertension, hypovolemic shock or right ventricular failure, etc.); 5. History of lung surgery or cranial surgery; 6. Combined with severe heart, liver, kidney and other systemic diseases; 7. Communication impairment (hearing and/or language), unable to complete the interview assessment before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral Blood Flow Parameters of the Middle Cerebral Artery (MCA);Bilateral Optic Nerve Sheath Diameter (ONSD);Arterial oxygen partial pressure;Arterial carbon dioxide partial pressure;Arterial blood pH;Arterial blood lactate;Regional cerebral oxygen saturation (rSO?);Perioperative cognitive function; | — |
Countries
China
Contacts
Public ContactQingming Bian
Jiangsu Provincial Cancer Hospital; Jiangsu Provincial Institute of Cancer Prevention and Control; Cancer Hospital of Nanjing Medical University
Outcome results
None listed