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A cohort study on the effects of marginal vitamin A deficiency in early life on neurobehavioral development

The role of SIRT1 regulation of circadian rhythm homeostasis in the effects of marginal vitamin A deficiency on neurobehavioral development in early life

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104862
Enrollment
Unknown
Registered
2025-06-25
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurobehavioral developmental problems

Interventions

Observation group:None

Sponsors

International Peace Maternity & Child Health Hospital of China Welfare Institute
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1.Women aged 20 and above; 2.Women admitted to our hospital in the third trimester of pregnancy (28-40 gestational weeks); 3.Pregnant women who do not plan to move out of Shanghai within five years; 4.Pregnant women who plan to establish a file and give birth in our hospital.

Exclusion criteria

Exclusion criteria: 1. Pregnant women with intellectual disorders; 2. High-risk pregnancy (suffering from diseases that may affect the neurodevelopment of the fetus, such as gestational diabetes, hypertension, epilepsy, etc.); 3. Pregnant women with symptoms induced by psychological illness or physical disease; 4. Pregnant woman with liver or kidney diseases that may affect VA metabolism or thyroid metabolic diseases; 5. Pregnant women (or her husband) with a family history of genetic diseases; 6. Newborns with conditions that may affect the neurodevelopment, such as an Apgar score of less than 7 and a birth weight of less than 2500g; 7. Twins or multiple pregnancies; 8. Abnormal hearing in newborns.

Design outcomes

Primary

MeasureTime frame
Vitamin A levels in umbilical cord blood;Ages & Stages Questionnaires, Third Edition, ASQ-3 Score;Bayley Scales of Infant and Toddler Development, Third Edition Score ;Child Behavior Checklist Score;

Countries

China

Contacts

Public ContactYu Ting

International Peace Maternity & Child Health Hospital of China Welfare Institute

yuting0510@sjtu.edu.cn+86 21 6407 0434

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026