Recovery Quality
Conditions
Interventions
Esketamine group :Esketamine 50mg was diluted to 10ml and prepared to 5mg/ml, the stock solution of cyclopofol injection was extracted to 20ml, that is, 2.5mg/ml, remifentanil was formulated to 10ug/m
0.9% NaCl group:10ml of 0.9% Nacl injection was extracted, the stock solution of cyclopofol injection was extracted to 20ml, that is, 2.5mg/ml, remifentanil was prepared as 10ug/ml, and cis-atracurium
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients who voluntarily undergo tracheoscopy under general anesthesia and sign relevant informed consent; 2. Gender is not limited, age 65~85 years old; 3. American Society of Anesthesiologists (ASA) grade I~III 4. Body mass index 18~30kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to the drugs used in the study or have contraindications to anesthesia; 2. Severe liver and kidney dysfunction (such as elevated serum aminotransferases>=2.5 times the upper limit of normal, serum creatinine level >=176.8umol/L); 3. Severe cardiopulmonary insufficiency (such as heart failure, respiratory failure) 4. Patients with poorly controlled hypertension (systolic blood pressure > = 180 mmHg and/or DBP > = 100 mmHg after taking antihypertensive drugs) or diabetes mellitus (glycosylated hemoglobin > = 9%); 5. Long-term opioid users or alcoholics; 6. Severe hearing, vision, intellectual disability and mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome was quality of recovery (QoR-15) scores on postoperative days 1 and postoperative days 2; | — |
Secondary
| Measure | Time frame |
|---|---|
| The individual QoR-15 scores for each of the 15 items;Blood pressure, heart rate, and oxygen saturation at 1 minute before anaesthesia induction (T0), 1 minute after anesthesia induction(T1), during laryngeal mask placement (T2), during the passage of the bronchoscope through the vocal cords (T3), and at the time of laryngeal mask removal (T4);The incidence of overall adverse events occurring;The total dosage of anaesthetic agents used (mg/kg);Cough severity ;The satisfaction rates among patients, pulmonologists, and anaesthesiologists; | — |
Countries
China
Contacts
Public ContactNa Xing
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed