Postoperative cognitive dysfunction
Conditions
Interventions
Esketamine group:Intravenous anesthesia with Esketamine
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age >= 65 years old, preoperative MMSE score >= 24 points, ASA grade 1 - 3, and able to communicate normally before surgery.
Exclusion criteria
Exclusion criteria: 1. With a history of severe mental disorders in the past. 2. Patients with untreated hypertension or poorly controlled blood pressure. 3. Patients with glaucoma or a history of eye surgery. 4. Patients with long - term alcoholism. 5. Patients with abnormal liver and kidney function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA cognitive function score;MMSE Mini - Mental State Examination Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time from drug withdrawal to tracheal extubation;Dosage of opioid drugs;number of times of severe fluctuations in intraoperative blood pressure and blood oxygen;number of occurrences of postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactMeng Yujie
The First Hospital of Shanxi Medical University
Outcome results
None listed