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Comparison of analgesic efficacy of liposomal bupivacaine single-point versus two-point thoracic paravertebral nerve block after double-microbore thoracoscopy

Comparison of analgesic efficacy of liposomal bupivacaine single-point versus two-point thoracic paravertebral nerve block after double-microbore thoracoscopy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104841
Enrollment
Unknown
Registered
2025-06-24
Start date
2025-06-25
Completion date
Unknown
Last updated
2025-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative chronic pain

Interventions

Single-point nerve block group:Inject 1.33% 266 mg bupivacaine liposome 20 ml at the T5-6 level.
Two-point nerve block group:10 ml of 1.33% 266 mg bupivacaine liposome is injected at T4-5 and T6-7 levels.

Sponsors

The Second Affiliated Hospital of the Air Force Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients who intend to undergo double microporous thoracoscopic partial lung resection (lung wedge, lung segment, lobe) under general anesthesia; 2. Age>= 18 years old; 3. BMI index 18-30kg/m^2; 4. ASA Grading I to II; 5. Voluntarily sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Refusal to participate in this study; 2. Communication disorders, unable to cooperate with the researcher, such as language comprehension disorders, psychiatric disorders, epilepsy, Parkinson's disease history or myasthenia gravis, etc.; 3. Confirmed/suspected persons with a history of alcohol, analgesic drugs or other drug abuse and addiction; 4. Those who are allergic to the drug in this study; 5. Long-term chronic pain before surgery; 6. Previous history of thoracic surgery; 7. In the opinion of the doctor in charge or the investigator, there are other conditions that are not suitable for participating in this study (the reasons need to be recorded).

Design outcomes

Primary

MeasureTime frame
Area under the acute pain score curve within 72 hours after surgery;

Secondary

MeasureTime frame
Postoperative PCIA use;Incidence of chronic pain at three months postoperatively;The amount of analgesic medication used by the patient after surgery;Postoperative pulmonary complication rate;Postoperative drain indwelling time;Number of days in hospital;Incidence of postoperative nausea and vomiting;

Countries

China

Contacts

Public ContactChangjun Gao

The Second Affiliated Hospital of the Air Force Military Medical University

gaocj74@163.com+86 29 8477 7439

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026