Pregnancy
Conditions
Interventions
Dexmedetomidine group(Dex group):/After umbilical cord clamping, the Dex group was injected with a loading dose of dexmedetomidine 0.5 µg/kg for 10 minutes, and then continuously infused at a rate of
Esketamine group(E group):After umbilical cord clamping, group E was injected with a loading dose of esketamine 0.15 mg/kg for more than 1 min, and then continued to be infused at a rate of 0.15 mg/kg
Sponsors
Sir Run Run Hospital Nanjing Medical University
Eligibility
Sex/Gender
Female
Age
22 Years to 34 Years
Inclusion criteria
Inclusion criteria: Full-term singleton pregnancies undergoing cesarean section under neuraxial anesthesia; aged 22-34 years; BMI 18-35kg/m^2;ASA physical status II.
Exclusion criteria
Exclusion criteria: There are contraindications to neuraxial anesthesia; placental abruption or placenta previa or umbilical cord prolapse;fetal distress or abnormal fetal heartbeat;hypertensive disorders of pregnancy; supine position syndrome during pregnancy; severe cardiac arrhythmias; abnormal thyroid and adrenal gland functions during pregnancy;hepatic and renal insufficiency;allergies to related narcotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure;Heartrate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Grading of visceral traction response;Medication situation during the surgery for parturients.;The situation of fluid intake and output during the surgery of the parturient.;Ramsay score; | — |
Countries
China
Contacts
Public ContactWang Liang
Sir Run Run Hospital Nanjing Medical University
Outcome results
None listed