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Diagnostic gene biomarkers for renal interstitial fibrosis revealed through bioinformatics analysis and experiments

Diagnostic gene biomarkers for renal interstitial fibrosis revealed through bioinformatics analysis and experiments

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104811
Enrollment
Unknown
Registered
2025-06-24
Start date
2025-06-28
Completion date
Unknown
Last updated
2025-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The diagnostic criteria for chronic kidney disease (CKD) refer to long-term damage to the structure and function of the kidneys, lasting for more than three months, typically characterized by a gradual decline in the function of the renal tubules and glomeruli, resulting in the inability of the kidneys to clear waste and excess water from the body. It is a progressive disease that may ultimately l

Interventions

CKD5 patients:NA
CKD1 patients:NA
CKD3 patients:NA

Sponsors

Shanghai General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Age range: 30-60 years old; 2. Meets the diagnostic criteria for Chronic Kidney Disease (CKD) and is diagnosed as CKD stage 1, 3, or 4-5; 3. Agree to provide renal pathology sections, 5ml blood and 10ml urine samples, and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1.Special populations: children, adolescents, pregnant women; 2.Specific types of nephropathy: IgA nephropathy, diabetes nephropathy, hereditary related nephropathy (such as Alport syndrome, polycystic kidney, etc.), hypertension related renal damage; 3.Combined serious diseases: recent severe infections or immune related kidney damage, combined cancer, severe cardiovascular disease and other systemic diseases.

Design outcomes

Primary

MeasureTime frame
differentially expressed genes;Potential diagnostic biomarkers;

Countries

China

Contacts

Public ContactRong Shu

Shanghai General Hospital

jingweisy@126.com+86 21 63240090

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026