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Evaluation of the application of multi-gene methylation markers combined with epidemiology and SNPs in the screening of upper gastrointestinal cancer: A multi-center prospective observational cohort study

Evaluation of the application of multi-gene methylation markers combined with epidemiology and SNPs in the screening of upper gastrointestinal cancer: A multi-center prospective observational cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104806
Enrollment
Unknown
Registered
2025-06-24
Start date
2025-06-30
Completion date
Unknown
Last updated
2025-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal Diseases

Interventions

Sponsors

The First Affiliated Hospital of Air Force Medical University/National Clinical Research Center for Digestive Diseases
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 74 Years

Inclusion criteria

Inclusion criteria: 1. The subjects were over 45 years old at the time of enrollment; 2. Plan to undergo upper gastrointestinal endoscopic screening; 3. Agree to conduct a two-year follow-up as per the plan; 4. Be willing and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Undergo upper gastrointestinal endoscopic screening within one year; 2. History of any type of malignant tumor; 3. The screening benefits are reduced due to severe diseases, such as severe lung diseases, kidney diseases, liver diseases, cardiovascular and cerebrovascular diseases, and blood diseases, etc. 4. Other situations where doctors assess endoscopic screening as having excessive risks (such as hemodynamic instability) or no benefits (short life expectancy); 5. Pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
Gastroscopy;SEPT9 gene methylation detection;RNF180 gene methylation detection;MT-1A gene methylation detection;Epo gene methylation detection;SNP detection;

Countries

China

Contacts

Public ContactYongzhan Nie

The First Affiliated Hospital of Air Force Military Medical University

zhengrong4956@163.com+86 198 2975 8242

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026