End-stage liver diseases
Conditions
Interventions
Control group (healthy individuals):NA
Liver cirrhosis group:NA
Acute-on-chronic liver failure (ACLF) group:NA
Sponsors
Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients aged 18-60 years with liver cirrhosis were enrolled, who voluntarily participated and signed informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Patients diagnosed with acute-on-chronic liver failure (ACLF) at admission; 2. A family history of diabetes mellitus and/or confirmed diagnosis of diabetes mellitus prior to the onset of liver disease; 3. Secondary diabetes caused by pituitary, adrenal, or thyroid disorders, or primary diabetes (particularly type 2 diabetes mellitus); 4. Concurrent hepatocellular carcinoma (HCC), hepatorenal syndrome (HRS), hepatic encephalopathy, or gastrointestinal bleeding at admission; 5. Coexisting hepatotropic viral hepatitis, drug-induced liver injury, or autoimmune-associated liver diseases; 6. Comorbidities including other malignancies, tuberculosis, or severe dysfunction of vital organs (heart, brain, lungs, kidneys); 7. Long-term use of immunosuppressants and/or glucocorticoids; 8. Active infection or antibiotic use within one week prior to hospitalization; 9. Acquired immune deficiency (e.g., HIV/AIDS); 10. Lactating or pregnant women; 11. Family history of glucose-6-phosphate dehydrogenase (G6PD) deficiency; 12. Hematologic disorders; 13. Incomplete clinical or biochemical data or loss to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete blood count (CBC);Blood biochemistry;Glucose metabolism-related parameters;Neutrophil function assay;Endoplasmic reticulum (ER) stress-related protein detection; | — |
Countries
China
Contacts
Public ContactSide Li
Affiliated Hospital of Zunyi Medical University
Outcome results
None listed