viral hepatitis
Conditions
Interventions
Exposure group:None
Control group:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18 years old, gender is not limited; 2. Diagnosed with viral hepatitis-related liver cirrhosis, with or without liver cancer; 3. In the decompensated stage of liver cirrhosis (there is one of the conditions such as ascites, gastrointestinal bleeding, hepatic encephalopathy, renal dysfunction, etc.); 4. No symptoms and signs of peritonitis at the time of admission; 5. Ascites examination has not been done or ascites examination has been performed, and ascites PMN =7 days.
Exclusion criteria
Exclusion criteria: 1. Non-hospitalized patients; 2. Expected possible death within 72 hours of admission; 3.ICU admitted patients; 4. Those who have a clear source of intra-abdominal infection; 5. Those who have received probiotics or antimicrobial drugs within 1 week before enrollment; 6. Those who have other serious diseases or complications that may affect the results or safety of the trial; 7. Pregnant, lactating women or those who plan to become pregnant during the trial; 8. Personnel who do not meet the inclusion criteria or do not meet the ethical requirements; 9. Subjects who are allergic to or intolerant to probiotics; 10. Persons with mental illness, consciousness disorders, or other conditions that cannot cooperate with treatment; 11. Persons who are participating in other clinical trials; 12. Persons who have peritonitis or secondary intraperitoneal infection at the time of admission; 13. Those who are considered unsuitable for enrollment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of SBP during hospitalization;Discharge outcome: Recovery, symptom relief, difficult to determine (hospitalization time too short to determine), transfer to other hospitals without recovery, death, automatic discharge but expected to die soon, other circumstances; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU occupancy rate during hospitalization;Incidence of SBP 30 days after discharge;The readmission rate within 30 days of discharge and the incidence of readmission due to SBP;The incidence of adverse events related to probiotics; | — |
Countries
China
Contacts
Public ContactZhiyong Zong
West China Hospital of Sichuan University
Outcome results
None listed