Knee osteoarthritis
Conditions
Interventions
Observation group:Celecoxib 0.2g (200mg) capsule orally twice daily+Supine Knee Flexion Rollback and Supine Leg Kick Strength Exercise
Control group:Celecoxib 0.2g (200mg) capsule orally twice daily+Quadriceps Isometric Contraction Combined with Straight Leg Raise Exercise
Sponsors
The Affiliated TCM Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients meeting the diagnostic criteria for Knee Osteoarthritis (KOA) who have achieved clinically effective discharge after treatment; (2) Individuals aged 50-75 years who are capable of independent movement; (3) Presence of crepitus in the knee joint, limited range of motion, and/or knee joint deformity; (4) Radiographic evidence classified as grade II or III according to the Kellgren-Lawrence criteria, with patients experiencing acute episodes of pain with a visual analog scale (VAS) score of 4 or below after treatment; (5) All participants signed an informed consent form voluntarily.
Exclusion criteria
Exclusion criteria: (1) Patients with osteoarthritis requiring surgical treatment. (2) Patients with a history of other medication use within the past 3 months. (3) Patients with fractures caused by trauma, local acute inflammation, knee joint tumors, or tuberculosis. (4) Patients with knee joint deformities or those suffering from neurovascular disorders in the lower limbs. (5) Patients with chronic or recurrent pain (other than knee osteoarthritis) requiring analgesics (such as acetaminophen, NSAIDs, compound over-the-counter medications containing analgesic ingredients, traditional Chinese medicines that may contain analgesic active ingredients, or topical analgesics). (6) Patients with cognitive impairment, underlying diseases, mental illnesses, as well as pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index;Visual Analogue Scale;Knee range of motion measurement; | — |
Countries
CHINA
Contacts
Public ContactBaoxin Liu
The Affiliated TCM Hospital of Guangzhou Medical University
Outcome results
None listed