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The Role of Oral and Gut Microbiota in the Pathogenesis and Diagnosis of Osteoarthritis: A Mechanistic Study

The Role of Oral and Gut Microbiota in the Pathogenesis and Diagnosis of Osteoarthritis: A Mechanistic Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104749
Enrollment
Unknown
Registered
2025-06-23
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

Osteoarthritis inflammation group:No intervention
Non-inflammatory group of osteoarthritis:No intervention

Sponsors

Weifang People's Hospital, Shandong Second Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Age: Over 18 years old, no gender restrictions. Diagnosis: Patients diagnosed with osteoarthritis according to the "Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2021 Edition)". Course of the disease: The course of the disease is at least 6 months. Symptoms: There are obvious symptoms such as joint pain, swelling or functional impairment. Agree: The patient or their legal guardian has fully understood the research content and voluntarily signed the informed consent form. Degree of cooperation: Patients are willing and able to cooperate to complete all research steps in accordance with the research protocol.

Exclusion criteria

Exclusion criteria: Patient exclusion criteria: Other diseases: Suffering from other serious diseases that may affect the research results, such as rheumatoid arthritis, gout, etc. Infection: Patients who are currently experiencing active infection or have a history of severe infection within the past three months. Immunosuppression: Patients who are currently using immunosuppressants or have immune deficiencies. Surgery: Patients who have undergone joint surgery within the past six months. Medication use: Currently using medications that may affect joint inflammation, such as long-term high-dose use of steroids. Pregnant or breastfeeding: Women who are pregnant or breastfeeding. Mental condition: Patients with severe mental disorders who are unable to understand the research content or provide informed consent. The researcher's judgment: Other circumstances where the researcher deems it inappropriate to participate in the research.

Design outcomes

Primary

MeasureTime frame
microbiota;Inflammatory indicators;

Countries

China

Contacts

Public ContactFeng Yikuan

Weifang People's Hospital, Shandong Second Medical University

651663729@qq.com+86 536 824 8223

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026