tardive dyskinesia
Conditions
Interventions
Tardive dyskinesia group:NA
Non tardive dyskinesia group:NA
Sponsors
Peking University Sixth Hospital ( Institute of Mental Health )
Eligibility
Sex/Gender
All
Age
12 Years to 19 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for the TD Group: 1. Age: 12–19 years; 2. Medication History: At least 3 months of prior use of medications associated with TD (e.g., antidepressants, antipsychotics, calcium channel blockers, or other TD-inducing drugs); 3. Symptom Assessment for TD Group: Must meet the criteria assessed by the Abnormal Involuntary Movement Scale (AIMS), defined as either: Moderate involuntary movements (AIMS score >=3) in at least one body region, or Mild involuntary movements (AIMS score >=2) in at least two body regions; 4. Informed Consent: Voluntarily sign the informed consent form and agree to participate in the study. Inclusion Criteria for the Non-TD Group: 1. Age: 12–19 years; 2. Medication History: At least 3 months of prior use of medications associated with TD (e.g., antidepressants, antipsychotics, calcium channel blockers, or other TD-inducing drugs); 3. Symptom Exclusion: No involuntary movements observed in any body region during medication use; 4. Informed Consent: Voluntarily sign the informed consent form and agree to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Exclusion of other conditions that may cause involuntary movements, such as hereditary dystonia, Huntington’s chorea, Sydenham’s chorea, or similar disorders; 2. Individuals unable to complete genetic testing, imaging studies, or scale assessments due to intellectual disability, severe physical illness, or other limiting conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abnormal Involuntary Movement Scale, AIMS;Clinical Global Impression Scale, CGI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale, PANSS;Neuropsychiatric Inventory, NPI;Hamilton Depression Scale, HAMD;Brief Psychiatric Rating Scale, BPRS;Extrapyramidal Symptom Rating Scale, ESRS;Tardive Dyskinesia Rating Scale, TDRS;Montreal Cognitive Assessment, MoCA;Mini-mental State Examination, MMSE; | — |
Countries
China
Contacts
Public ContactBai Chaobo
Peking University Sixth Hospital ( Institute of Mental Health )
Outcome results
None listed