general surgical operation
Conditions
Interventions
oliceridine group:Five minutes before anesthesia induction, 0.03mg/kg of oxelidine was administered, followed by 0.3mg/kg of etomidate. It was observed for 2 minutes to determine whether myoclonus occ
control group:5 minutes before anesthesia induction, an equal volume of normal saline, and then 0.3 mg/kg etomidate, 2 minutes to observe whether myoclonus occurs and assess the severity. Intravenous
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18~65 years old, gender not limited; 2.Patients who are scheduled to undergo general surgery under general anesthesia at the First Affiliated Hospital of Naval Medical University; 3. ASA classification: Level I-II; 4. The anesthesia method is general anesthesia; 5. The patients or the patient's family members have carefully read and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. BMI>30kg/m^2; 2. Diagnosed clinically as adrenal cortex dysfunction, including but not limited to adrenal cortex dysfunction (such as Addison's disease) and adrenal cortex hyperfunction (such as Cushing's syndrome); 3. Patients with neurological or psychiatric disorders; 4. History of drugs allergies; 5. Severe liver and kidney dysfunction; 6. Severe cardiovascular disease; 7. Those who take painkillers, sedatives, or opioid drugs within 24 hours; 8. Patients who participated in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myoclonus incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Myoclonus severity;Incidence of adverse effects such as dizziness, bradycardia, hypotension, and hallucinations due to ocellidine pretreatment.; | — |
Countries
China
Contacts
Public ContactLulong Bo
Shanghai Changhai Hospital
Outcome results
None listed