Pneumonia
Conditions
Interventions
Observation group:None
Sponsors
The Army Characteristic Medical Center of the People's Liberation Army of China
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age >=18 years old; 2) Meet the diagnostic criteria of "Guidelines for the diagnosis and treatment of community-acquired pneumonia (2023 edition)" of Chinese Respiratory Society. The diagnosis should be confirmed by at least one senior respiratory physician. 3) Bronchoscopy is clinically necessary (e.g., to confirm the diagnosis, rule out lung cancer, tuberculosis, or other diseases, or for topical treatment such as alveolar lavage); 4) The diagnosis of CAP should be made within one week for both outpatients and inpatients; 5) Patients or their legal representatives voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Previous history of lung transplantation; 3. There are contraindications to bronchoscopy, including but not limited to: 1) Severe cardiopulmonary dysfunction, unable to tolerate bronchoscopy; 2) coagulopathy with a risk of bleeding (meets either criteria) : a. Coagulation function shows a hypocoagulable state; b. platelet count = 0.4); b. Oxygenation index (PaO2/FiO2) <= 150 mmHg (or <= 20 kPa); 4) severe arrhythmia or unstable angina; 4. Patients with severe systemic diseases and expected survival time less than 3 months (such as advanced malignant tumors, end-stage organ failure, etc.); 5. Received chemotherapy, radiotherapy or immunosuppressive therapy within 2 weeks before admission (special cases need to be reviewed by the ethics committee); 6. If the sample size of BALF was not sufficient for metabolomics analysis (if the amount of BALF recovered during the operation was too small to meet the needs of subsequent detection, it was excluded);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction rate of CT score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blod routine and infammatoryindicators (white blod cels, neutrophis, ymphocytes, ymphogyte subsets, platelets, -reactive protein, procalcitonin, serum amyloid protein,intereukin-6, TNF-a;PaO2/FiO2; | — |
Countries
China
Contacts
Public ContactLi Li
The Army Characteristic Medical Center of the People's Liberation Army of China
Outcome results
None listed