Colorectal tumors
Conditions
Interventions
Experimental group :Ultrasound-guided transversus abdominis plane block with dexamethasone and ropivacaine
Control group:Ultrasound-guided transversus abdominis plane block with ropivacaine
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. It is planned to electively undergo laparoscopic radical colorectal resection under general anesthesia; 2. 18 years old< = age< = 80 years old, gender is not limited; 3.18 kg/m^2<=BMI<=28 kg/m^2; 4. Patients with American Society of Anesthesia (ASA) grade I.~III.
Exclusion criteria
Exclusion criteria: 1. Subjects with a history of traumatic surgery in the abdomen and incomplete recovery after treatment; 2. Subjects with a history of new myocardial infarction or unstable angina within 6 months prior to randomization; 3. Subjects with a history of ischemic stroke or transient ischemic attack (TIA); 4. Subjects with psychiatric diseases (such as schizophrenia, depression, etc.) and cognitive dysfunction; 5. Concomitant other physical pain that may affect postoperative pain assessment; 6. History of severe or refractory postoperative nausea or vomiting; Persistent or recurrent nausea and/or vomiting due to other causes, including, but not limited to, gastric pyloric obstruction, hypercalcemia, or active peptic ulcer; 7. Abnormal laboratory test results during the screening period: (1) fasting blood glucose (FPG) >=10.0mmol/L; (2) Abnormal liver function: aspartate aminotransferase (AST) or/and alanine aminotransferase (ALT) and/or total bilirubin (TBiL) >=1.5×ULN; (3) Abnormal renal function: serum creatinine (Cr) >=1.5×ULN, or dialysis subjects; (4) Abnormal coagulation function: PT> upper limit of normal value 3s and/or APTT > upper limit of normal value 10s; (5) Platelets (PLT). 8. Concomitant drugs: (1) Known allergies or contraindications to ropivacaine or other amide local anesthetics and other drugs that may be used during the test, such as propofol, lidocaine, opioids, etc.; (2) Use of anti-arrhythmic drugs or drugs that affect liver metabolism within the first 5 drug half-lives of randomization; (3) intravenous or intra-articular corticosteroid injection; (4) Sedative drugs: benzodiazepines, benzodiazepines (such as diazepam, flurazepam, oxazepam, chlordiazepoxide, triazolam, alprazolam, estazolam, midazolam, etc.), diazepam, barbiturates, carbamazepine, phenytoin, magnesium sulfate (only external application is allowed, intravenous low-dose electrolyte supplementation is allowed), chloral hydrate, etc. 9. Those who refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative rebound pain within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Score of postoperative rebound pain;Numeric rating scale of postoperative pain;Opioid usage;Recovery Quality;Adver event;Hospitalization days; | — |
Countries
China
Contacts
Public ContactWang Hongqian
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed