Postoperative Pulmonary Complications and Ventilator-Induced Lung Injury
Conditions
Interventions
Control group (Group M, conventional ventilation group):Standard mechanical ventilation without additional interventions
Experimental group (Group N, low mechanical power ventilation group):Mechanical power-minimizing ventilation strategy
Sponsors
Tianjin Third Central Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing laparoscopic colorectal surgery under general anesthesia and aged >=60 years; 2. The estimated operation time is greater than 3 hours; 3. American Society of Anesthesiologists (ASA) grade II.~III. before surgery; 4. Cardiac function I.~II. 5. Body mass index (BMI) 18.5~30 kg/m^2; 6. Preoperative pulmonary function tests showed mild obstructive ventilatory dysfunction (60%< FEV1<80% or FEV1/FVC <50%~70% of the predicted value).
Exclusion criteria
Exclusion criteria: 1.Patients with a history of allergy to anesthetic agents; 2.Obese patients with body mass index (BMI) >30 kg/m^2; 3.Severe hepatic/renal dysfunction, cardiopulmonary insufficiency, or psychiatric disorders; 4.Active pulmonary infection or pleural effusion within one week prior to surgery; 5.Pre-existing respiratory organic diseases (e.g., chronic obstructive pulmonary disease, bronchial asthma, pulmonary bullae, or spontaneous pneumothorax); 6.Conditions affecting thoracic compliance (e.g., pectus carinatum, pectus excavatum, or history of thoracic surgery/trauma); 7.Intraoperative conversion to open laparotomy; 8.Cases with incomplete data due to experimental record loss.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peak airway pressure, Ppeak;Mean Airway Pressure, Paw;Airway Plateau Pressure, Pplat;Driving Pressure, DP;Mechanical Power, MP;Postoperative Pulmonary Complications, PPCs;Dead Space/Tidal Volume Ratio, VD/VT;Time to tracheal extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygenation Index, OI;Respiratory Index, RI; | — |
Countries
China
Contacts
Public ContactHaiyun Wang
Tianjin Third Central Hospital
Outcome results
None listed