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Clinical Study on the Application of Autogenous Tooth Bone Graft Powder in Periodontally Accelerated Osteogenic Orthodontics (PAOO) for Adult Orthodontic Patients

Clinical Study on the Application of Autogenous Tooth Bone Graft Powder in Periodontally Accelerated Osteogenic Orthodontics (PAOO) for Adult Orthodontic Patients

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104704
Enrollment
Unknown
Registered
2025-06-22
Start date
2023-06-02
Completion date
Unknown
Last updated
2025-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malocclusion

Interventions

Experimental group:ATB (made from the patients own extracted teeth) is used as bone graft material in PAOO

Sponsors

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-40 years old, general and periodontal health; 2. Patients who have received orthodontic treatment or orthodontic orthognathic combination therapy 3. The orthodontic program includes a meiotic tooth extraction program, and the amount of tooth extraction >= 2 molars or >= 4 premolars (at least meet the bone increment of single anterior tooth area); 4. Those who meet the indications of PAOO surgery (including but not limited to those with thin alveolar bone on the labial side of the lower anterior tooth area, bone opening and window bone cracking in the lower anterior tooth area, crowded dentition, and thin alveolar bone on the labial side of individual teeth, etc.); 5. The patient undergoes PAOO surgery in the lower anterior tooth area; 6. Those who agree to participate in this study.

Exclusion criteria

Exclusion criteria: 1. There is extensive caries or restorations and root canal fillings in the extracted teeth, and the remaining available tooth tissue is insufficient; 2. Patients with syndromes such as dentin dysplasia; 3. The tooth extraction program includes the lower anterior teeth or the lower anterior teeth are missing; 4. Pregnant or lactating women; 5. Patients with tumors or systemic serious diseases; 6. Patients with acute oral and maxillofacial infection; 7. Patients with moderate or progressive periodontitis; 8. Patients who have received chemoradiotherapy.

Design outcomes

Primary

MeasureTime frame
Multiple measurement levels of alveolar bone thickness (ABT4, ABT6, ABT8, ABTM, ABTA);

Secondary

MeasureTime frame
Alveolar crest height (ACH);Alveolar bone area (ABA);Root length (RL);Sagittal root position (SRP);Bone defect;Pain;Discomfort;Swelling;Chewing difficulty;Swallowing difficulty;Limited mouth opening;

Countries

China

Contacts

Public ContactXuepeng Chen

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine.

cxp1979@zju.edu.cn+86 159 6715 2776

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026