The Effect of Intravenous Lidocaine Infusion on Postoperative Pain in Patients Undergoing Laparoscopic Radical Gastrectomy for Gastric Cancer

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500104701

Enrollment

Unknown

Registered

2025-06-20

Start date

2025-06-20

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Interventions

Lidocaine group:Anesthesia induction: Lidocaine 1.5mg/kg injected slowly (completed within 10 minutes)

Anesthesia maintenance: Lidocaine infused at a rate of 1.5mg/kg/h until the end of surgery

Control group:Anesthesia induction and maintenance are administered with an equal volume of 0.9% saline

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective laparoscopic radical gastrectomy for gastric cancer; 2. Aged 18-75 years, with ASA classification of I-III; 3. Clear consciousness, normal comprehension ability, able to independently and clearly answer questions; 4. Fully understand and voluntarily participate in this study, and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with pre-existing other acute or chronic pain; 2. Patients on long-term opioid medication; 3. Patients with a history of severe cardiovascular and cerebrovascular diseases, abnormal liver and kidney function, and endocrine disorders before surgery; 4. Patients with a history of mental illness or current mental abnormalities; 5. Patients who use psychotropic and sedative-hypnotic drugs long-term; 6. Patients with known allergies to the drugs and ingredients used in this study; 7. Patients with cognitive impairments and speech expression defects, making it difficult to cooperate with the investigator.

Design outcomes

Primary

Measure	Time frame
The incidence of moderate to severe pain induced by exercise 24 hours after the operation;Remedy analgesia rate within 48 hours;Perioperative adverse event occurrence(Hypotension, bradycardia, arrhythmia, etc.);	—

Secondary

Measure	Time frame
Visceral Pain Score During Exercise and at Rest;Exercise and rest incision pain scores;Opioid consumption;Recovery quality within 24h, 48h, and 72h after surgery;	—

Countries

China

Contacts

Public ContactZiyang Chen

The First Affiliated Hospital of Nanjing Medical University

chenzy0627@126.com+86 135 1251 6397

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026