Atrial fibrillation
Conditions
Interventions
Sponsors
Shanghai Pudong New Area Zhoupu Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.[ Experimental Group ] (1) Age: 20-90 years old; (2) Symptomatic, non-valvular paroxysmal or persistent atrial fibrillation (with a duration of =1 week), and unresponsive to one or more antiarrhythmic drugs; (3) The patient is preparing to undergo atrial fibrillation ablation surgery; (4) Provide informed consent forms indicating willingness to participate in the study, compliance with the follow-up trial and assessment procedures. 2.Healthy Control Group: (1) Age: 20-90 years old; (2) No history of major physical diseases (diseases of important organs such as the heart, liver, kidneys, and brain), no history of major infectious diseases or exposure to infectious diseases, no history of mental illness or family history. (3) Physical examination and laboratory tests (blood and urine routine, blood biochemistry, electrocardiogram, chest X-ray) found no abnormalities or abnormalities but had no clinical significance; (4) The subjects gave informed consent and voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.[ Experimental Group ] (1) There are acute lesions, such as the acute stage after myocardial infarction (within 3 months), acute attack of heart failure or within 3 months after a new cerebral infarction; (2) On the list of heart transplants; (3) Life expectancy is less than one year; (4) There are other hemorrhagic diseases and anticoagulant therapy cannot be carried out; (5) Left atrial thrombosis (6) Patients with cardiac insufficiency at New York Heart Classification grades 3-4 or EF<40%; (7) Patients with uncontrolled cancer; (8) Obvious liver and kidney function damage (and/or ALT and AST levels are more than twice the upper limit of the normal value, CCr<50%); (9) Previous history of catheter radiofrequency ablation for atrial fibrillation or cardiac surgery; (10) Women who are pregnant, breastfeeding, planning to become pregnant, or women of childbearing age who have not adopted reliable contraceptive methods. Healthy Control Group: (1) There has been a history of infection, fever, trauma or burn surgery within the past month; (2) Have taken any drugs (Western medicine or traditional Chinese medicine) for the prevention and treatment of cardiovascular and cerebrovascular diseases within the past month; (3) Women who are pregnant, breastfeeding, planning to become pregnant, or women of childbearing age who have not adopted reliable contraceptive methods. (4) Currently suffering from or having previously suffered from mental system disorders such as depression, anxiety, and substance abuse; (5) Unable to cooperate in completing this research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cfDNA methylation; | — |
Countries
China
Contacts
Public ContactZhaoxia Wang
Shanghai Pudong New Area Zhoupu Hospital
Outcome results
None listed