Hip Fracture Surgery
Conditions
Interventions
Intervention group:Continuous intravenous infusions of combined lidocaine (0.1 mg/kg/hour), dexmedetomidine (3 ug/kg), and sufentanil (1 ug/kg) were started before the skin incision and continued for
Control group:Continuous intravenous infusion of dexmedetomidine (3 ug/kg) and sufentanil (1 ug/kg) was started before skin incision and continued for 48 hours.
Sponsors
The People's Hospital of Jizhou District, Tianjin
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Clinical or imaging diagnosis of intracapsular or extracapsular hip fracture 2. Planned surgical treatment by hemi-hip arthroplasty, total hip arthroplasty, or appropriate fixation surgery 3. Age>=50 years
Exclusion criteria
Exclusion criteria: 1. ASA physical condition classification >=IV 2. Patients weighing outside the range of 40-100kg 3. Patients who have delirium before surgery 4. Contraindications to lidocaine and dexmedetomidine 5. Allergy to the study drug 6. Plan postoperative mechanical ventilation 7. Patients with known or suspected patients are at high risk of malignant hyperthermia 8. Inability to communicate or understand study instructions 9. Patients with a history of drug abuse (such as ketamine, cocaine, heroin, amphetamines, phencyclidine, lysergic acid, mescalin, psilocybin) 10. Patients with neurological disorders or taking antipsychotic drugs (such as chlorpromazine, clozapine, olanzapine, risperidone, haloperidol, quetiapine, paliperidone, amisulpride, sertralindole) 11. Severe heart disease (such as severe aortic stenosis, severe heart block, A-S syndrome, pre-excitation syndrome) 12. Patients with renal or hepatic impairment 13. Patients who are unable to correct electrolyte imbalances 14. Refusal of the patient or authorized agent to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rescue opioids use;Acute postoperative pain;Patient satisfaction;Quality of recovery;Hospital length of stay;Chronic pain; | — |
Countries
China
Contacts
Public ContactTengjiao Zhang
The People's Hospital of Jizhou District, Tianjin
Outcome results
None listed