Skip to content

Effect of bupivacaine liposomes in multimodal analgesic regimen on postoperative analgesic effects and prognosis of total hip arthroplasty patients under the concept of accelerated rehabilitation surgery

Effect of bupivacaine liposomes in multimodal analgesic regimen on postoperative analgesic effects and prognosis of total hip arthroplasty patients under the concept of accelerated rehabilitation surgery

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104686
Enrollment
Unknown
Registered
2025-06-20
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Femoral neck fracture

Interventions

Bupivacaine liposome group (LB group):When PENG block was performed, 10mL of LB (133mg) + 5mL of normal saline was injected. When performing the cocktail therapy, a total of 40mL (LB 133mg, compound b
Ropivacaine group (ROP group):When performing PENG block, 10mL (100mg) of ropivacaine and 5mL of normal saline were injected. When performing the cocktail therapy, a total of 40mL (a 40mL mixture made

Sponsors

Panzhihua Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1.Patients undergoing total hip arthroplasty (THA) for the first time, regardless of gender; 2. Age >= 18 years old; 3. Have communication skills; 4. American Society of Anesthesiologists (ASA) grades I, II, and III.

Exclusion criteria

Exclusion criteria: 1.Refuse to sign the consent form; 2. History of opioid abuse; 3. History of alcohol addiction 4. Unwilling or unable to abide by the agreement procedures; 5. Patients who are allergic to the drugs used during anesthesia; 6. Systemic or puncture site infection; 7. Patients with abnormal blood coagulation and abnormal platelet count; 8. Patients with gastric ulcers who are contraindicated for flurbiprofen axetil; 9. Patients with severe arrhythmia, heart failure, respiratory diseases, and liver or kidney dysfunction;

Design outcomes

Primary

MeasureTime frame
The NRS scoring method was adopted. The pain scores of the two groups of patients at rest and during activity were obtained at 6, 12, 24, 48 and 72 hours after the operation;Consumption of sufentanil in the analgesic pump;The number of compressions of the analgesic pump and the usage rate of flurbiprofen axetil in the ward;Postoperative hospital stay;Postoperative complications of the two groups of patients (including postoperative arrhythmia, postoperative stroke, unexpected transfer to the ICU, pulmonary infection, respiratory failure, postoperative heart failure, unplanned secondary surgery, incision infection, and in-hospital death);

Secondary

MeasureTime frame
The occurrence of adverse reactions (including postoperative nausea and vomiting, dizziness and headache, and urinary retention) within 72 hours after the operation in the two groups of patients;Postoperative recovery conditions of the two groups of patients (including the time of first drinking, eating, leg movement and walking after the operation);

Countries

China

Contacts

Public ContactBangjian Zhang

Panzhihua Central Hospital

376243940@qq.com+86 180 9630 7256

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026