acute ST-segment-elevation myocardial infarction
Conditions
Interventions
control group:conventional therapy of ST-segment elevation myocardial infarction (STEMI)
nicorandil group:conventional therapy for ST-segment elevation myocardial infarction (STEMI) combined with nicorandil
Sponsors
Chongqing Emergency Medical Center, Chongqing University Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-80 years, regardless of gender; 2. Clinically diagnosed STEMI patients within 12 hours of onset, scheduled for emergency PCI; 3. Voluntary participation in this clinical study with written informed consent provided.
Exclusion criteria
Exclusion criteria: 1. Systolic blood pressure <100 mmHg; 2. Cardiogenic shock; 3. Complicated with aortic dissection; 4. History of myocardial infarction or revascularization within the past 6 months (excluding the current event); 5. Current use of nicorandil; 6. Known allergy, hypersensitivity, or contraindication to nicorandil; 7. Severe hepatic or renal dysfunction; 8. Severe cerebral dysfunction; 9. Patients with right ventricular myocardial infarction; 10. Patients with angle-closure glaucoma; 11.Allergy to nitrates or nitrite esters; 12. Participation in another clinical study within the past 3 months or currently enrolled; 13. Pregnant or breastfeeding women; 14. Severe mental disorders impairing the ability to express consent; 15. Presence of other significant abnormal signs, laboratory findings, or clinical conditions deemed unsuitable for participation by the investigator; 16. Unwillingness to participate in the trial or refusal to sign the informed consent form.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| incidence of major adverse cardiovascular events ; | — |
Primary
| Measure | Time frame |
|---|---|
| incidence of ventricular arrhythmias; | — |
Countries
China
Contacts
Public ContactGang Xu
Emergency Medical Center, Chongqing University Central Hospital
Outcome results
None listed