Acute Respiratory Distress Syndrome
Conditions
Interventions
Control group:PEEP setting refering to Clinical physician's decision
EIT group:EIT PEEP titration
P-V curve group:P-V curve PEEP titration
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age >18 years; 2. Patients diagnosed with ARDS according to the Berlin Definition criteria; 3. PaO2/FiO2 ratio =72 hours; 5. Planing to perform at least 1 extended prone position ventilation.
Exclusion criteria
Exclusion criteria: 1.Hemodynamic instability, defined as norepinephrine infusion rate >0.4 µg/kg/min and/or concurrent life-threatening arrhythmias; 2.Prone positioning duration <16 hours; 3.Contraindications to prone positioning, such as glaucoma, flail chest, pregnancy, or other unsuitable conditions; 4.Patients who decline to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| day 28 mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| non-dependent to dependent ventilation ratio (ND/D);Blood gas PaO2/FIO2 ratio;Blood gas PaCO2;Respiratory mechanics index;Hospital mortality; | — |
Countries
China
Contacts
Public ContactLing Sang
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed