A prospective cohort study of Major Depressive Disorder

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500104681

Enrollment

Unknown

Registered

2025-06-20

Start date

2025-01-08

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder

Interventions

Case series:None

Eligibility

Sex/Gender

All

Age

14 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. The age of the patient is 14-60 years old, and the gender is not limited; 2. Meet The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) MDD diagnostic criteria, can be first or relapse; 3. Hamilton Depression Scale (HAMD-17) score >=14 points; 4. Patients who have not received treatment for the last 14 days of this depressive episode; 5. Primary school education, can understand the content of the scale; 6. To understand and voluntarily participate in this study, I or legal guardian sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Have a current or past DSM-5 significant diagnosis other than MDD; 2. Have a history of serious organic diseases of important systems or organs; 3. Pregnant or lactating female patients; 4. Participants in interventional clinical trials within 3 months; 5. The investigator judged that the compliance was poor or not suitable for the participants.

Design outcomes

Primary

Measure	Time frame
Hamilton Depression Rating Scale (24-item);Hamilton Anxiety Rating Scale-14 item;	—

Secondary

Measure	Time frame
Patient Health Questionnaire-9;Resting-state electroencephalogram (EEG);Actigraphy recorder data;Generalized Anxiety Disorder 7-item;Mood Disorder Questionnaire;Clinically Useful Depression Outcome Scale-Modified;Childhood Trauma Questionnaire;Snaith-Hamilton Pleasure Scale ;Internet Addiction Test;Adolescent Self-Rating Life Events Checklist ;Connor-Davidson Resilience Scale ;Perceived Stress Scale-14 item;Abbreviated Scale for Suicide History and Risk;Negative Appraisal Inventory ;Scale for Suicidal Ideation and Behavior ;Subjective Well-Being Scale ;Gait;eye movement,;facial expression;voice and video;heart rate variability;	—

Measure

Time frame

Patient Health Questionnaire-9;Resting-state electroencephalogram (EEG);Actigraphy recorder data;Generalized Anxiety Disorder 7-item;Mood Disorder Questionnaire;Clinically Useful Depression Outcome Scale-Modified;Childhood Trauma Questionnaire;Snaith-Hamilton Pleasure Scale ;Internet Addiction Test;Adolescent Self-Rating Life Events Checklist ;Connor-Davidson Resilience Scale ;Perceived Stress Scale-14 item;Abbreviated Scale for Suicide History and Risk;Negative Appraisal Inventory ;Scale for Suicidal Ideation and Behavior ;Subjective Well-Being Scale ;Gait;eye movement,;facial expression;voice and video;heart rate variability;

—

Countries

China

Contacts

Public ContactWang Yumei

Shandong First Medical University

17652941966@163.com+86 173 0223 2650

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026