Glioma
Conditions
Interventions
Oncolytic virus detection group of organoids:NA
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 70 years old; 2. Karnofsky Performance Status (KPS) score >= 60; 3. The diagnosis by histopathology was primary/recurrent glioblastoma. 4. Patients with measurable or evaluable lesions confirmed by MRI, with an expected survival of at least 12 weeks, and who consent to surgical resection of the lesion. 5. Have sufficient bone marrow function to receive subsequent adjuvant therapy (white blood cell count >= 4000/µL, neutrophil count >= 1500/µL, platelet count >= 100,000/µL, hemoglobin >= 8.0g/dL), renal function (serum creatinine <= 150µmol/L, 24-hour urine protein <= 3.4g) and liver function (total bilirubin <= 34µmol/L, aspartate and alanine aminotransferase <= 120U/L). 6. The patient is capable of understanding and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Extracranial metastatic disease; 2. Has received or is currently undergoing treatment with carmustine wafer implants (Gliadel); 3. Severe cardiopulmonary insufficiency; 4. status epilepticus; 5. Pregnant or lactating women; 6. gastrointestinal bleeding; 7. Blood pressure (>140/90mmHg) after uncontrolled medication use; 8. There are frequent vomiting, difficulty in swallowing or other conditions that affect oral administration of drugs. 9. HIV positive and antiretroviral therapy; 10. Patients who are currently participating in other clinical trials or have previously participated and have not yet completed the trials. 11. Other conditions that the researchers consider unsuitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival;objective response rate; | — |
Countries
China
Contacts
Public ContactGuanglong Huang
Southern Medical University Southern Hospital
Outcome results
None listed