type-2 diabete with smoking
Conditions
Interventions
GLP-1 group:Application of GLP-1RAs drugs
DPP-IV group:Taking oral medications containing DPP-IV
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnosis of type 2 diabetes mellitus; 2.Male and the age is between 18 and 75 years old; 3.Smoked for at least one year; 4.The Fagerstrom Test for Nicotine Dependence (FTND) score of >=4; 5.Understand the trial and will take part in it voluntarily, willing to sign a consent form; 6.Fit to use GLP1-RAs and DPP-IV inhibitors as the treatment but didn’t use them before;
Exclusion criteria
Exclusion criteria: 1.type 1 diabetes mellitus or special types of diabetes; 2.Diabetic patients with ketoacidosis and patients with severe diabetic complications; 3.Patients with severe heart, liver, kidney, brain, immune, and blood system diseases; 4.Patients with severe infection, malignant tumor, before and after surgery, and severe trauma; 5.Have a history of severe recurrent hypoglycemia; 6.Patients with severe gastrointestinal diseases (i.e., severe gastroparesis); 7.Previous history of pancreatitis or risk of pancreatitis; 8.Poor compliance, unwilling or unable to follow-up on time; 9.Severe psychiatric illness such as schizophrenia, paranoid psychosis, bipolar disorder, or intellectual disability; 10. Contraindications to magnetic resonance scanning (magnetic implants, pacemakers, claustrophobia, etc.)
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Functional MRI changes;Laboratory test indicators;Exhaled CO;General condition and adverse reactions; | — |
Primary
| Measure | Time frame |
|---|---|
| Fagerstrom Test of Nicotine Dependence (FTND) scores; | — |
Countries
China
Contacts
Public ContactJun Song
Shanghai East Hospital
Outcome results
None listed