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A Study on the Effects of Siraitia grosvenorii on the Healing of Peri-implant Tissues Following Dental Implant Surgery in Patients with Chronic Periodontitis

A Study on the Effects of Siraitia grosvenorii on the Healing of Peri-implant Tissues Following Dental Implant Surgery in Patients with Chronic Periodontitis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104646
Enrollment
Unknown
Registered
2025-06-20
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental arch defect, Chronic periodontitis

Interventions

Group III:(positive control group):Patients with chronic periodontitis received implant surgery after basic periodontal treatment and were not supplemented with loquat fruit.
Group II:Patients with chronic periodontitis received implant surgery after basic periodontal treatment and were supplemented with intervention with Siraitia grosvenorii.
Group I: (control group):Patients with periodontal health who received implant surgery

Sponsors

The Affiliated Stomatological Hospital of GuangXi Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.18 to 65 years old, gender not limited; 2.Patients with chronic periodontitis who have good periodontal health or whose inflammation has been controlled through basic periodontal treatment; 3.The loss of a single tooth meets the indications for simple implantation; 4.There should be at least one healthy adjacent tooth between the proximal and distal parts of the missing tooth site. 5. Good oral hygiene and regular follow-up visits are available.

Exclusion criteria

Exclusion criteria: 1. Uncontrolled inflammation in adjacent teeth or the surgical site. 2.Systemic or local bone diseases such as osteoporosis, bone cysts, or bone tumors. 3.History of radiotherapy or chemotherapy within the past 5 years. 4.Pregnant or lactating women, or those planning pregnancy within 1 year. 5. Long-term use of specific medications (e.g., corticosteroids, anticoagulants, bisphosphonates). 6. Psychiatric or neurological disorders (e.g., epilepsy). 7. Uncontrolled endocrine/metabolic diseases, hematologic disorders, or cardiovascular diseases. 8. Heavy smokers (>10 cigarettes/day) or individuals with poor oral hygiene habits. 9. Other conditions deemed unsuitable for participation by the investigators.

Design outcomes

Primary

MeasureTime frame
The changes of subgingival plaque around the implant;Visual Analogue Scale for Pain;The changes of inflammatory factors in gingival crevicular fluid around the implant;Changes in the overall condition;Landry healing index of soft tissue healing;The changes of alveolar bone around the implant;

Countries

China

Contacts

Public ContactXiaoxia Zhong

The Affiliated Stomatological Hospital of GuangXi Medical University

595494487@qq.com+86 771 5358349

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026