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Methodological study on the detection of fetal blood group by different concentrations of cff-DNA in the peripheral blood of pregnant women

Methodological study on the detection of fetal blood group by different concentrations of cff-DNA in the peripheral blood of pregnant women

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104641
Enrollment
Unknown
Registered
2025-06-20
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hemolytic disease of the fetus and newborn

Interventions

Gold Standard:Collecting umbilical cord blood after birth and using serological methods to detect blood types
Index test:Detection of fetal free DNA in peripheral blood of pregnant women and fetal blood type

Sponsors

Air Force Medical Center
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Pregnant women with blood type O ; Pregnant women with blood type RhD negative; Pregnant women who are both blood type O and RhD negative

Exclusion criteria

Exclusion criteria: Pregnant women with blood type O and their spouse with blood type O; RhD negative pregnant women with RhD negative spouse; Twin pregnancy; Injection of anti-D immunoglobulin

Design outcomes

Primary

MeasureTime frame
ABO blood group genes;RhD blood group genes;ABO blood group;RhD blood group;sensitivity;specificity;accuracy;Youden index;Kappa consistency test;—

Countries

China

Contacts

Public ContactLi Cuiying

Air Force Medical Center,Air Force MedicalUniversity

licuiying2013@qq.com+86 156 1116 5639

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026