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Clinical research protocol for predicting the risk of esophageal varices in patients with compensated cirrhosis based on non-invasive indicators of liver and spleen stiffness

Clinical research protocol for predicting the risk of esophageal varices in patients with compensated cirrhosis based on non-invasive indicators of liver and spleen stiffness

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104636
Enrollment
Unknown
Registered
2025-06-20
Start date
2024-03-12
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Compensated cirrhosis

Interventions

Gold Standard:Gastroscopy was performed and esophageal varices were graded according to the standard Trial Protocol for Endoscopic diagnosis and treatment of Gastrointestinal Varices and Bleeding in C
Index test:Liver stiffness (LSM) and spleen stiffness (SSM)

Sponsors

Hunan Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age of 18-80 years old; 2. cirrhosis diagnosed by ultrasound, CT, magnetic resonance imaging or liver biopsy; 3.All patients underwent gastroscopy. Informed consent was obtained from all patients.

Exclusion criteria

Exclusion criteria: 1. Decompensated events occurred, including ascites (abdominal ascites >=30mm by B-ultrasound), esophagogastric variceal bleeding, and hepatic encephalopathy; 2.previous endoscopic treatment; 3.previous splenectomy; 4. previous TIPS; 5. portal vein thrombosis or cavernous transformation of portal vein; 6.using NSBB; 7.primary or secondary liver tumors; 8.Compression of portal vein and splenic vein by upper abdominal space occupying lesions; 9. obstruction of hepatic vein and inferior vena cava; 10. alanine aminotransferase >=5×ULN, total bilirubin >=3mg/dL; 11.pregnant women; 12.right heart failure; 13.Blood system diseases.

Design outcomes

Primary

MeasureTime frame
Liver stiffness;Spleen stiffness (SSM);

Countries

China

Contacts

Public ContactZheng Zhang

Hunan Provincial People's Hospital

7535411@qq.com+86 13617481199

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026