pharmacology
Conditions
Interventions
Group 1 (Stage 1):Cypofol for injection was given a fixed dose of 0.4mg/kg, and different doses of remifentanil were given sequentially (initial dose 0.3ug/kg, dose gradient 0.1ug/kg).
Group 2 (Stage 2):Administer different doses of ciprofol sequentially via intravenous injection, followed by the intravenous administration of the ED95 dose of remifentanil determined in the previous
Sponsors
Shunde Hospital Affiliated to Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-59 years old, gender unlimited; 2. ASA grade I or II. 3. Elective laryngeal mask surgery under general anesthesia; 4. The patient volunteered to participate in the study; 5. No contraindications of general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Full stomach without fasting; 2. cardiopulmonary insufficiency; 3. There is a tumor in the pharynx; 4. Small mouth opening, laryngeal mask Difficult to place; 5. Patients with obstructive sleep apnea hypopnea syndrome or BMI>30 kg/m^2 or respiratory difficulties; 6. Surgery is expected to be older.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ED50 and ED95 of remifentanil;The ED50 and ED95 of ciprofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate;Chest wall rigidity;Allergic reaction;Bradycardia; Hypotension;Jaw relaxation;Gag reflex;Biting on laryngeal mask airway;Coughing;Body movement; | — |
Countries
China
Contacts
Public ContactHuang Bixin
Shunde Hospital Affiliated to Jinan University
Outcome results
None listed