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Clinical observation and study of low-dose esketamine on sleep disorders in elderly patients after joint replacement surgery

Clinical observation and study of low-dose esketamine on sleep disorders in elderly patients after joint replacement surgery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104624
Enrollment
Unknown
Registered
2025-06-19
Start date
2024-08-19
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep disorders in elderly people

Interventions

Test group:Before anesthesia induction,esketamine 0.25mg/kg was administered continuously by pump during surgery at an injection rate of 0.3mg/kg/h
Control group:No use of esketamine, normal anesthesia

Sponsors

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Ersha Island Branch of Guangdong Hospital of Traditional Chinese Medicine)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Undergoing total hip or total knee arthroplasty treatment; 2. Age 65-85 years old, male or female; 3. Voluntarily participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Body mass index higher than 30; 2. Preoperative Pittsburgh Sleep Quality Index (PSQI) higher than 7; 3. Patients who are allergic to esketamine or have contraindications to esketamine; 4. Cognitive dysfunction or inability to communicate.

Design outcomes

Primary

MeasureTime frame
Anson Douleur de l’Accouchement Scale Score;Numeric Rating Scale, NRS;

Secondary

MeasureTime frame
Pittsburgh Sleep Quality Index;Anxiety and depression scores;

Countries

China

Contacts

Public ContactChenpu Wei

Ersha Island Branch of Guangdong Hospital of Traditional Chinese Medicine

weichenpu_0@126.com+86 136 0245 0857

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026