chronic rhinosinusitis with nasal polyps(CRSwNP)
Conditions
Interventions
Experimental group 1: Both sides of the surgical area were packed with Nasopore soaked with mometasone furoate.: Both sides of the surgical area were packed with Nasopore soaked with mometasone furoat
Experimental group 2: One side of the surgical area was packed with Nasopore soaked with mometasone furoate, and the other side was packed with Nasopore soaked with normal saline.:One side of the surg
Control group: Both sides of the surgical area were packed with Nasopore soaked with normal saline.:Both sides of the surgical area were packed with Nasopore soaked with normal saline.
Sponsors
The affiliated Yangchuan hospital of Chongqing medical university
Eligibility
Sex/Gender
All
Age
16 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Research Subjects: Sixty patients with CRSwNP admitted to the Department of Otorhinolaryngology-Head and Neck Surgery of Yongchuan Hospital Affiliated to Chongqing Medical University from January 2025 to June 2025 were selected as the research subjects. According to the random number table method, the patients were divided into experimental group 1, experimental group 2, and control group, with 20 cases in each group. The age range was from 16 to 75 years old, and both genders were included. 2. Meeting the diagnostic criteria in "Chinese Guidelines for the Diagnosis and Treatment of Chronic Rhinosinusitis (2018)". 3. Accompanied by symptoms such as nasal congestion, headache, runny nose, and olfactory disorder, and with a Visual Analogue Scale (VAS) score >= 4; 4. Receiving nasal surgery for the first time and meeting the indications for FESS surgery; 5. Being conscious, with normal communication ability and good compliance; 6. The patient and family members provided informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with severe complications. 2.Patients with combined dysfunctions of vital organs, hematological diseases, autoimmune diseases, or parasitic infections. 3.Patients with combined sinus malignancies, atrophic rhinitis, or fungal infections of the nasal cavity and sinuses. 4.Patients with intellectual disabilities or mental illnesses. 5.Patients who have used hormonal drugs within 3 months prior to the initiation of this study. 6.Patients with surgical contraindications or those allergic to the therapeutic drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sino-Nasal Outcome Test-22;Sinus CT Lund - MacKay Score;Endoscopic Lund-Kennedy Score ;Post - operative endoscopic assessment (POSE);Plasma cortisol concentration;serum inflammatory factors;Peripheral blood lymphocyte subsets;Expression of zonula occludens - 1 (ZO - 1) in sinus mucosal tissue; | — |
Secondary
| Measure | Time frame |
|---|---|
| Olfactory testing method;Nasal airway resistance is evaluated by rhinometry.;Nasal mucosal function; | — |
Countries
China
Contacts
Public ContactPi Jingting
The affiliated Yangchuan hospital of Chongqing medical university
Outcome results
None listed