Skip to content

Integrated Multi-omics Profiling of Coronary Endarterectomy Specimens for the Construction of a Personalized Molecular Landscape of Coronary Artery Disease

Integrated Multi-omics Profiling of Coronary Endarterectomy Specimens for the Construction of a Personalized Molecular Landscape of Coronary Artery Disease

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104613
Enrollment
Unknown
Registered
2025-06-19
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis

Interventions

Coronary Heart Disease Multi-omics Classification 1:None
Coronary Heart Disease Multi-omics Classification 2:None
Coronary Heart Disease Multi-omics Classification 3:None
Coronary Heart Disease Multi-omics Classification 4:None

Sponsors

Shanghai Tenth People’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients with a definitive diagnosis of stable or unstable coronary artery disease (CAD) who have been clinically evaluated as requiring coronary endarterectomy (CE) (2) Aged >18 years (3) Capable of comprehending the study objectives, voluntarily agreeing to participate, and having signed the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Diffuse coronary small vessel disease; Extensively calcified and non-operable coronary arteries; End-stage coronary artery disease with no revascularization value; Active phase of acute myocardial infarction; Severe left ventricular dysfunction (ejection fraction 80 years old) with multiple systemic comorbidities; (3) Severe hepatic or renal insufficiency; (4) Coagulation disorders or bleeding diathesis; (5) History of stroke within the past 6 months; (6) Patients with limited life expectancy (<1 year); (7) History of multiple coronary interventions leading to vascular structural changes; (8) Severe chronic pulmonary disease; (9) Participants who have participated in or are currently participating in any other clinical trial involving devices or medications within the past 3 months; (10) Other circumstances deemed by the investigator as unsuitable for clinical trial participation. This translation maintains medical terminology accuracy while ensuring clarity and readability for clinical research contexts.

Design outcomes

Primary

MeasureTime frame
cardiovascular and cerebrovascular events;

Countries

China

Contacts

Public ContactWenliang Che

The Tenth People's Hospital affiliated to Tongji University

chewenliang@tongji.edu.cn+86 189 1768 4081

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026