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Exploring the Molecular Mechanism and Application of Endothelin-1 in Distant Metastatic Papillary Thyroid Carcinoma Based on Human Tumor Organoids

Exploring the Molecular Mechanism and Application of Endothelin-1 in Distant Metastatic Papillary Thyroid Carcinoma Based on Human Tumor Organoids

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104600
Enrollment
Unknown
Registered
2025-06-19
Start date
2024-11-12
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Papillary Thyroid Carcinoma

Interventions

Observation Group:None

Sponsors

The Affiliated Hospital of Southwest Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Signed informed consent and related ethical documents, and age >=18 years; 2. Intraoperative frozen section and postoperative pathological examination confirming PTC; 3. Specimen confirmed by two pathology experts, with cancer cell content in tumor tissue >70%, and no cancerous lesions in adjacent normal tissue; 4. Complete clinical data available.

Exclusion criteria

Exclusion criteria: 1. Other types of thyroid cancer; 2. Mixed-type thyroid cancer (i.e., containing two or more types of thyroid cancer); 3. History of previous neck surgery; 4. History of prior neck radiation or iodine-131 treatment; 5. History of benign thyroid disease; 6. History of other malignancies; 7. Family history of thyroid disease.

Design outcomes

Primary

MeasureTime frame
EDN1;—

Countries

China

Contacts

Public ContactXiangyu Zhou

The Affiliated Hospital of Southwest Medical University

xiangyuzhou971@vip.126.com+86 15983048222

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026