None
Conditions
Interventions
Moderate exercise group without exercise habits:The subjects in this group were those who had no exercise training habits before enrollment. The weekly exercise program is designed to achieve a total
Have exercise habits and maintain moderate exercise group:The subjects of this group were the people who had exercise habits before enrollment. The weekly exercise program is designed to achieve a tot
Group with exercise habit and step up exercise:The subjects of this group were the people who had exercise habits before enrollment. The total met value of weekly high-intensity exercise was 800-1200.
Sponsors
Xiangtan First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Healthy Subjects: 1.18.5=18 years and <=40 years; 3. Physical and mental health; 4. Those who have good compliance with the experiment and can participate in high-intensity exercise after physical examination; 5. The patient or a close relative can fully understand the informed consent, agree to participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Participated in any interventional clinical study (including drug/device/biologics trial) within 3 months prior to enrollment; 2. History of major systemic disease (subject to clinical significance), details as follows: (1) Circulatory system diseases (such as coronary heart disease, hypertension above level II., severe arrhythmia) (2) Metabolic endocrine diseases (diabetes, hyperthyroidism/hypothyroidism, etc., urological diseases (chronic kidney disease stage 3 and above); (3) Neurological diseases (epilepsy, sequelae of stroke, etc.); (4) Immune system abnormalities (primary/acquired immunodeficiency, autoimmune diseases); (5) Other systemic diseases (blood system, respiratory system, psychiatric diseases, etc.); 3. Requirements for renal function limitation (serum creatinine needs to be tested by standardized testing methods) The CockcroftGault formula calculates creatinine clearance (CrCl) < 80 mL/min; CrCl = [(140-age) × body weight (kg)] / [0.814 × Scr(µmol/L)] 4. Abnormal clinical examination, any of the following clinically significant abnormalities (as judged by the investigator) at the time of enrollment: abnormal signs of physical examination, pathological changes in ECG, laboratory test values exceeding the normal range by more than 20%, significant abnormalities in ultrasound/radiological imaging, and persistent deviation of vital signs from the baseline value; 5. Other circumstances that are not suitable for selection: There are special circumstances that affect the integrity of the study or the safety of subjects as comprehensively assessed by the research team.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin condition assessment;Exercise cardiopulmonary test;Muscle mass and quality assessment;Muscle function test;Imaging examination;Other necessary indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory test indicators;Anthropometric index;Muscle tissue biopsy; | — |
Countries
China
Contacts
Public ContactGenqing Xie
The first people's hospital of Xiangtan hospital
Outcome results
None listed