Squamous cell carcinoma of the oesophagus
Conditions
Interventions
Gold Standard:Patients with healthy oesophagus were identified by the clinician (investigator) taking into account the patients chief complaint, past medical history, and imaging, and patients with oe
Index test:Salivary exosome KPNA2 gene
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for patients with esophageal squamous cell carcinoma: (1) Confirmed diagnosis of esophageal squamous cell carcinoma; (2) Age >=50 years. 2. Inclusion criteria for healthy patients: (1) Age >=50 years old. (2) Healthy subjects: All healthy subjects were recruited in public places (such as parks, elderly activity centers, shopping areas, or hospital physical examination centers).
Exclusion criteria
Exclusion criteria: Exclusion criteria for oesophageal squamous cell carcinoma patients: (1) Those who have received anticancer treatments such as surgery, radiotherapy and chemotherapy; (2) Combined with other malignant tumours; (3) Combined with serious oral disease, lung disease, renal or hepatic dysfunction, severe hypertension, diabetes mellitus. (3) People with severe oral disease, lung disease, renal or hepatic dysfunction, severe high blood pressure, diabetes; (4) Those who refuse or are unable to sign the informed consent form. Healthy patients exclusion criteria: Healthy controls were excluded if they had any history of cancer, severe oral disease, diabetes mellitus, pulmonary disease, liver and kidney dysfunction, severe immune system changes, etc. Healthy controls with severe immune changes and cardiovascular events in the past 6 months were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the receiver operating characteristic curve (AUC-ROC);Accuary;Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactWang Luowei
Shanghai Changhai Hospital
Outcome results
None listed